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Synthesize distinct electrophysiological approaches examining the mechanisms by which intracellular calcium and membrane voltage control large-conductance (BK) potassium channel gating.

August 1, 1999The Journal of General PhysiologyOpen Access

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BK channels

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SJStephen W. JonesUniversity of North Carolina at Chapel Hill

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This commentary highlights that recent studies on BK channel gating support allosteric models similar to the MWC model.

Key Points

Synthesize distinct electrophysiological approaches examining the mechanisms by which intracellular calcium and membrane voltage control large-conductance (BK) potassium channel gating.
Evaluated single-channel patch-clamp recordings measured at +30 mV under saturating calcium concentrations.
Analyzed macroscopic ionic and gating currents measured across a broad voltage range in the nominal absence of calcium.
Both single-channel and macroscopic current analyses converged on allosteric gating mechanisms rather than direct sequential activation.
BK channel gating dynamics qualitatively parallel the classical Monod-Wyman-Changeux (MWC) model for allosteric protein transition.

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Population

BK channels

This commentary highlights that recent studies on BK channel gating support allosteric models similar to the MWC model.

Cite This Study

Stephen W. Jones (1999) studied this question.

synapsesocial.com/papers/6a71daf831a3df824329d816 https://doi.org/10.1085/jgp.114.2.271

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Commentary

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