Key result
SSRI use in patients with coronary artery disease had conflicting effects on cardiovascular outcomes across 13 studies (5 showed benefit, 2 showed harm, and 6 showed no significant association).
Why the study?
Does selective serotonin reuptake inhibitor use reduce cardiovascular morbidity and mortality in patients with coronary artery disease and depression?
Population
Patients with coronary artery disease and depression (based on a review of 13 studies)
Design
Review
Authors
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Conflicting observational data should not change SSRI prescribing in CAD; leaves open net cardiovascular effects and requires RCTs.
Does selective serotonin reuptake inhibitor use reduce cardiovascular morbidity and mortality in patients with coronary artery disease and depression?
The current literature on SSRI use for cardiovascular outcomes in patients with coronary artery disease is predominantly observational and yields conflicting results, highlighting the need for randomized controlled trials.
Ruden et al. (2008) conducted a review in Coronary artery disease and depression. Selective serotonin reuptake inhibitors (SSRIs) was evaluated on Cardiovascular morbidity and mortality. SSRI use in patients with coronary artery disease had conflicting effects on cardiovascular outcomes across 13 studies (5 showed benefit, 2 showed harm, and 6 showed no significant association).
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