Key result
Spinal cord injury was associated with significantly increased QT dispersion compared to healthy controls (50.394 vs 41.039 ms, p=0.018), though P-wave dispersion did not differ significantly.
Why the study?
Does spinal cord injury affect P-wave and QT dispersion compared to healthy controls?
Observational (n=123)
Does spinal cord injury affect P-wave and QT dispersion compared to healthy controls?
Absolute Event Rate: 50.394% vs 41.039%
p-value: p=0.018
Spinal cord injury is associated with increased QT dispersion, suggesting a potential mechanism for increased ventricular arrhythmia susceptibility in this population.
May heighten ventricular arrhythmia vigilance in spinal cord injury; hypothesis-generating and requires prospective outcome studies.
OBJECTIVE: Spinal cord injury (SCI) can lead to significant cardiac arrhythmia. However, P-wave, QT dispersion, and risk factors in these patients have not been widely investigated. In this study, we assessed whether there is a relationship between electrocardiogram (ECG) parameters and risk factors in SCI patients. METHODS: The study population consisted of 85 SCI patients and 38 control subjects. P-wave durations were measured using 12 leads of the surface ECG. P-wave dispersion was defined as the difference between the P-wave maximum and P-wave minimum duration. QT dispersion was defined as the difference between the largest and smallest QT interval for any of the 12 leads (QTmax-QT-min). QT intervals were also corrected (QTc) in accordance with the heart rate using Bazett's formula (QT Interval/√[RR interval]). We also evaluated the independent risk factors for P-wave dispersion and QT dispersion in SCI patients. RESULTS: The P-wave minimum, P-wave maximum, QT minimum, and dispersion were significantly different between the control and SCI groups. There was no significant difference in P-wave dispersion, QT maximum, or QTc. Multivariate regression analysis showed that disease duration, glucose and high-density lipoprotein cholesterol (HDL-C) levels, and systolic tension were independent risk factors for P-wave dispersion. CONCLUSION: Our results demonstrate that QT dispersion is related to SCI and that P-wave dispersion was linked to the duration of SCI, HDL-C and glucose levels, and arterial tension in SCI patients.
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Akbal et al. (2014) conducted an observational in Spinal cord injury (n=123). Spinal cord injury vs. Healthy controls was evaluated on QT dispersion (ms) (p=0.018). Spinal cord injury was associated with significantly increased QT dispersion compared to healthy controls (50.394 vs 41.039 ms, p=0.018), though P-wave dispersion did not differ significantly.
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