Key result
A 5-year-old boy with a congenital heart defect developed thrombosis and warfarin-associated skin necrosis following multi-stage cardiac surgery and poorly controlled warfarin therapy.
Why the study?
Thrombotic complications occur in 3,6-13% of children with congenital heart defects postoperatively, and warfarin used for prevention can cause warfarin-associated skin necrosis.
Case Report (n=1)
Children with cyanotic congenital heart defects post-cardiac surgery are at high risk for thrombotic complications and require careful monitoring of anticoagulant therapy to prevent severe adverse events like warfarin-associated skin necrosis.
Warfarin necrosis risk persists in poorly controlled pediatric CHD anticoagulation post-surgery; leaves open safer monitoring or alternatives.
The thrombotic complications develop in 3,6–13% of children with congenital heart defects in the postoperative period, which makes the diagnosis and prevention of thrombosis relevant. Permanent risk factors include the carriage of mutations/polymorphic variants of genes, leading to an imbalance in the procoagulant and anticoagulant hemostatic systems. In some cases, children after cardiac surgery are prescribed anticoagulants, warfarin is the most commonly used vitamin K antagonist, which can cause warfarin-associated skin necrosis as a result of vascular microthrombosis of the microvasculature. We provide our own observation – a case of thrombosis and warfarin-associated skin necrosis in a child after a multi-stage correction of congenital heart defect on the background of indirect anticoagulant therapy.
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Гандаева et al. (2020) conducted a case report in Congenital heart defect, thrombosis, warfarin-induced skin necrosis (n=1). Warfarin was evaluated on Development of thrombosis and warfarin-associated skin necrosis. A 5-year-old boy with a congenital heart defect developed thrombosis and warfarin-associated skin necrosis following multi-stage cardiac surgery and poorly controlled warfarin therapy.
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