December 1, 1988Proceedings of the National Academy of SciencesOpen Access

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

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Population

Eight myelin basic protein-specific T-cell lines and clones with various H-2 restrictions and antigenic…

Comparison

Cop 1 vs D-Cop 1 and poly(Tyr,Glu,Ala) (TGA)

Design

Preclinical

Authors

DTDvora TeitelbaumTufts University RARina AharoniWeizmann Institute of Science RARuth ArnonWeizmann Institute of Science

Discussion

Member takes

Implication

Supports Cop 1 mechanism in EAE models; leaves open translation to human MS therapy.

Structured PICO

Population

Eight myelin basic protein (BP)-specific T-cell lines and clones with various H-2 restrictions and antigenic specificities

Intervention

Cop 1 (synthetic basic random copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine)

Comparator

D-Cop 1 and poly(Tyr,Glu,Ala) (TGA)

Outcome

T-cell response to myelin basic protein (BP) measured by cell proliferation and interleukin 2 secretion assayssurrogate

Cop 1 specifically inhibits myelin basic protein-specific effector T cells, providing a mechanism for its efficacy in suppressing experimental allergic encephalomyelitis.

Cite This Study

Teitelbaum et al. (1988) studied this question.

synapsesocial.com/papers/6a71de5dc2d7c3090827216d https://doi.org/10.1073/pnas.85.24.9724

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Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider