Key result
A fractionated chemotherapy approach successfully managed a patient with secondary cardiac diffuse large B-cell lymphoma presenting with sudden ventricular tachycardia and cardiogenic shock.
Case Report (n=1)
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A fractionated chemotherapy approach with CICU admission can successfully manage patients with cardiac DLBCL presenting with cardiogenic shock and ventricular tachycardia.
Extranodal involvement of non-Hodgkin lymphoma (NHL) has been reported in 20–40% of patients and has been typically observed in the skin, bones, gastrointestinal tract, liver and brain. Cardiac involvement has been reported in up to 20% of autopsy cases of patients with NHL and accounts for about 2% of all cardiac malignancies. Here, we report a peculiar case of a secondary cardiac diffuse large B-cell lymphoma (DLBCL), occurring with an abrupt hemodynamic instability, characterized by a sudden ventricular tachycardia and cardiogenic shock. The patient promptly started the first cycle of chemotherapy and was admitted to the cardiac intensive care unit (CICU) of our institution to prevent potential cardiovascular complications during treatment. We applied a fractionated treatment approach, progressively reaching standard doses, to decrease the risk of early death and ensure a successful management.
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Mariani et al. (2021) conducted a case report in Secondary cardiac diffuse large B-cell lymphoma (DLBCL) (n=1). Fractionated chemotherapy was evaluated. A fractionated chemotherapy approach successfully managed a patient with secondary cardiac diffuse large B-cell lymphoma presenting with sudden ventricular tachycardia and cardiogenic shock.
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