Key result
Complexes containing two myosin Va motors exhibited only slightly larger run lengths and appreciably lower velocities compared to single-myosin molecules, suggesting net negative cooperative behaviors.
Elastically coupled myosin Va motors exhibit negative cooperative behaviors, resulting in lower velocities and only slightly increased run lengths compared to single motors, driven by internal strain and high sensitivity of stepping rates to strain.
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May influence vesicle transport models in cells; leaves open extension to cardiac myosin function in vivo.
Lu et al. (2012) studied this question. Structurally-defined motor complexes containing two myosin Va (myoVa) motors vs. Single-myosin molecule was evaluated on Run lengths and velocities. Complexes containing two myosin Va motors exhibited only slightly larger run lengths and appreciably lower velocities compared to single-myosin molecules, suggesting net negative cooperative behaviors.
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