Key result
An outbreak of hand, foot, and mouth disease in a Spanish nursery school was followed by onychomadesis 36 to 69 days later, with 12 of 17 affected children developing nail shedding.
Observational (n=42)
No
This epidemiological study confirms onychomadesis as a delayed complication of hand, foot, and mouth disease in children.
Onychomadesis may follow HFMD outbreaks by 5–10 weeks in children; supports association but leaves open prospective confirmation.
Few reports exist regarding the association between onychomadesis and an enterovirus infection presenting clinically as hand, foot, and mouth disease (HFMD). In February 2009, an outbreak of HFMD occurred in a Spanish nursery school, followed by onychomadesis 36-69 days later. Twelve of 17 children with HFMD developed nail shedding; enterovirus was detected in stool samples from eight (47%) of the 17. However, in only three of the children could an enterovirus serotype coxsackievirus B1 be identified. The epidemiological results of this study confirm onychomadesis as a complication in HFMD. In future outbreaks, molecular characterization of enterovirus from appropriate clinical samples should be studied.
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Cabrerizo et al. (2010) conducted an observational in Hand, foot, and mouth disease (HFMD) and onychomadesis (n=42). Hand, foot, and mouth disease (HFMD) vs. No HFMD was evaluated on Development of onychomadesis. An outbreak of hand, foot, and mouth disease in a Spanish nursery school was followed by onychomadesis 36 to 69 days later, with 12 of 17 affected children developing nail shedding.
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