Key result
First-degree relatives of patients with arrhythmogenic right ventricular cardiomyopathy exhibited significantly lower longitudinal strain in the basal septum compared to healthy controls.
Why the study?
Does speckle tracking echocardiography detect subtle right or left ventricular dysfunction in first-degree relatives of patients with ARVC?
Population
58 males, including 17 patients with arrhythmogenic right ventricular cardiomyopathy fulfilling Task Force…
Comparison
Speckle tracking echocardiography for… vs Healthy controls and first-degree relatives.
Design
Cross-sectional, Observers blinded for inter/intra-observer variability and…
Authors
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Speckle tracking may detect subclinical dysfunction in ARVC relatives; hypothesis-generating, prospective validation needed before screening changes.
Cross-Sectional (n=58)
Single-blind
No
Does speckle tracking echocardiography detect subtle right or left ventricular dysfunction in first-degree relatives of patients with ARVC?
Absolute Event Rate: -15.8% vs -17.8%
p-value: p=0.025
Speckle tracking echocardiography combined with dimensional parameters into a novel index may help detect early subclinical ventricular dysfunction in ARVC mutation carriers.
Aneq et al. (2012) conducted a cross-sectional in Arrhythmogenic right ventricular cardiomyopathy (ARVC) (n=58). First-degree relative of ARVC patient vs. Healthy controls was evaluated on 2D longitudinal strain in the basal septum (%) (p=0.025). First-degree relatives of patients with arrhythmogenic right ventricular cardiomyopathy exhibited significantly lower longitudinal strain in the basal septum compared to healthy controls.
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