Population
18 autonomous thyroid adenomas (ATAs) and surrounding normal thyroid tissue (NTs)
Design
Other
Authors
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PDE4 induction may counter cAMP excess in TSHR-mutant adenomas; leaves open whether targeting this feedback alters nodule behavior.
Activating mutations in TSHR or Gsalpha in autonomous thyroid adenomas lead to a dramatic induction of PDE4, representing an intracellular feedback mechanism.
Persani et al. (2000) studied this question.
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