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It has been found that normal rabbits respond to the intravenous administration of Cx-reactive protein by producing this acute phase substance. When Cx-reactive protein incorporated in adjuvant is injected intracutaneously, in addition to producing Cx-reactive protein, the recipient animals develop a characteristic inflammatory reaction about the site of injection. This inflammatory reaction can be inhibited by the prior intravenous injection of thorotrast.
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Wood et al. (1957) studied this question.
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