Oxidative hemolysis is the name frequently given to the accelerated destruction of circulating human erythrocytes exposed to "oxidant stress." This designation is a misnomer because the process is most often associated with drugs and chemicals that are really reducing agents, not oxidizing compounds. The contradiction is partly resolved when the mechanisms thought to be responsible are considered. Currently, the following sequence of events has been formulated into a reasonable and popular hypothesis.1 The potentially hemolytic agent is converted into an active metabolite, which interacts with the oxygen of oxyhemoglobin to generate hydrogen peroxide (H2O2), peroxyhemoglobin, or . . .
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Ernst R. Jaffé (1972) studied this question.