Key result
Patients with cardiac amyloidosis had significantly worse global longitudinal strain (-15.7%) compared to those with hypertrophic cardiomyopathy (-18.0%) and Anderson-Fabry's disease (-21.9%).
Why the study?
Does CMR-measured longitudinal strain and LGE distribution differentiate cardiac amyloidosis from other causes of left ventricular hypertrophy?
Population
83 patients referred for CMR imaging with left ventricular hypertrophy, including 45 with confirmed cardiac…
Comparison
Cardiovascular magnetic resonance cine imaging… vs Comparison of imaging patterns between patients…
Design
Cohort, Strain analysis and LGE quantification were performed by independent…
Authors
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May support GLS for differentiating cardiac amyloidosis from HCM and Fabry disease; leaves open prospective validation.
Cohort (n=83)
Blinded observers for strain and LGE analysis
No
Does CMR-measured longitudinal strain and LGE distribution differentiate cardiac amyloidosis from other causes of left ventricular hypertrophy?
Absolute Event Rate: -15.7% vs -18%
p-value: p=0.046
CMR feature-tracking demonstrates relative apical sparing of longitudinal strain in cardiac amyloidosis, which correlates with a base-to-apex gradient in late gadolinium enhancement, aiding in differentiation from other causes of left ventricular hypertrophy.
Williams et al. (2016) conducted a cohort in Cardiac amyloidosis, hypertrophic cardiomyopathy, and Anderson-Fabry's disease (n=83). Cardiac amyloidosis vs. Hypertrophic cardiomyopathy and Anderson-Fabry's disease was evaluated on Global longitudinal strain (p=0.046). Patients with cardiac amyloidosis had significantly worse global longitudinal strain (-15.7%) compared to those with hypertrophic cardiomyopathy (-18.0%) and Anderson-Fabry's disease (-21.9%).
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