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February 1, 2016Heart

Prognostic implication of relative regional strain ratio in cardiac amyloidosis

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Why the study?

Does relative regional strain ratio (RRSR) predict death or heart transplantation in patients with cardiac amyloidosis?

Population

97 patients with cardiac amyloidosis diagnosed by endomyocardial biopsy or advanced imaging criteria coupled…

Design

Cohort

Follow-up

5 years

Authors

ASAlpana SenapatiHouston MethodistBSBrett W. SperrySaint Luke's Health SystemJGJustin L. GrodinHeart Failure & Transplant

Discussion

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Overview

May refine prognostication in cardiac amyloidosis; hypothesis-generating and requires prospective validation.

Structured PICO

Does relative regional strain ratio (RRSR) predict death or heart transplantation in patients with cardiac amyloidosis?

P
Population
97 patients with cardiac amyloidosis (AL n=59, ATTR n=38) diagnosed by endomyocardial biopsy or advanced imaging criteria coupled with either extracardiac biopsy or genetic analysis.
I
Intervention
Relative regional strain ratio (RRSR) measurement by echocardiography
O
Outcome
Composite of time to death or heart transplantation at 5 yearscomposite

High relative regional strain ratio (RRSR) on echocardiography is an independent predictor of death or heart transplantation in patients with cardiac amyloidosis.

Cite This Study

Senapati et al. (2016) studied this question.

synapsesocial.com/papers/6a8a805eb1e5d05ea8eca7dchttps://doi.org/10.1136/heartjnl-2015-308657
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Structure and Function in Transthyretin-Related Versus Light-Chain Cardiac Amyloidosis2014 · 351 citations
  2. 2Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis2015 · 44 citations
  3. 3Cardiac transthyretin amyloidosis2012 · 138 citations
  4. 4Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis2005 · 1,436 citations
  5. 5Prognostic significance of Doppler measures of diastolic function in cardiac amyloidosis. A Doppler echocardiography study.1991 · 357 citations