Why the study?
Does naloxone have different respiratory and circulatory effects compared to levallorphan and nalorphine in anaesthetised patients?
Does naloxone have different respiratory and circulatory effects compared to levallorphan and nalorphine in anaesthetised patients?
Naloxone lacks the respiratory depressant agonist activity seen with other narcotic antagonists like levallorphan and nalorphine.
Answers are grounded in this paper and cite their sources.
Naloxone may be preferred to minimize respiratory depression in anaesthetized patients; leaves open need for randomized confirmation in contemporary settings.
Naloxone, the n-ally1 derivative of the narcotic* analgesic oxymorphone, has been shown to possess narcotic antagonist properties, without obvious agonist activity, in animals and anaesthetised man."A comparison of the respiratory and circulatory effects of naloxone, levallorphan and nalorphine in anaesthetised patients demonstrated that, whereas naloxone had virtually no effect, the other drugs were respiratory depressant^.^When naloxone was administered in large doses to former narcotic
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Evans et al. (1974) studied this question.
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