Key result
Higher serum tPAI-1 levels were independently associated with pulmonary arterial hypertension severity, with an odds ratio of 1.02.
Why the study?
Markers other than mPAP for classifying PAH severity are not elucidated, and the relationship between serum tPAI-1, TM, and pulmonary circulation remains undetermined.
Population
100 consecutive patients with cardiac diseases undergoing right heart catheterization
Comparison
Serum coagulation and fibrinolytic marker levels across mPAP levels
Design
Retrospective study
Authors
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tPAI-1 and TM were associated with PAH severity; hypothesis-generating for noninvasive biomarkers, requiring prospective confirmation.
Observational (n=100)
No
Odds Ratio: 1.02 (95% CI 1–1.036)
p-value: p=0.034
Serum tPAI-1 and thrombomodulin levels correlate with mean pulmonary artery pressure and may serve as non-invasive predictors of severity in early-stage pulmonary arterial hypertension.
Shoji et al. (2021) conducted an observational in Pulmonary arterial hypertension (n=100). Serum tPAI-1 levels vs. Lower tPAI-1 levels was evaluated on Independent characteristic marker of PAH severity (mPAP ≥25 mmHg) (OR 1.02, 95% CI 1.000-1.036, p=0.034). Higher serum tPAI-1 levels were independently associated with pulmonary arterial hypertension severity, with an odds ratio of 1.02.
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