Population
In vitro model characterizing four monoclonal antibodies to human thrombomodulin
Design
Preclinical
Authors
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Suggests calcium modulates thrombomodulin function; leaves open relevance to in vivo coagulation or therapeutic targeting.
The study demonstrates that human thrombomodulin undergoes a calcium-dependent conformational change near its thrombin-binding site in the EGF-homology domain.
Kimura et al. (1989) studied this question.
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