Key result
Greater central arterial stiffness, measured by aortic pulse wave velocity, was significantly associated with lower hippocampal cerebral blood flow (R2 0.79) and lower N-acetyl aspartate concentration.
Why the study?
Central arterial stiffness is associated with elevated blood pressure and likely cerebral artery stiffening, hypoperfusion, neuronal loss, and cognitive decline, prompting exploration of its association with hippocampal blood flow and neuronal density in hypertensive Dahl-S rats.
Cross-Sectional (n=12)
No
Effect estimate: R2 0.79
p-value: p=<0.001
BACKGROUND: Central arterial stiffness (CAS) is associated with elevated arterial blood pressure (BP) and is likely associated with stiffening of cerebral artery walls, with attendant cerebral hypoperfusion, neuronal density loss and cognitive decline. Dahl salt-sensitive (Dahl-S) rats exhibit age-associated hypertension and memory loss, even on a normal salt intake. METHOD: We sought to explore whether central arterial pulse wave velocity (PWV), a marker of CAS, is associated with hippocampal cerebral blood flow (CBF) and neuronal density in hypertensive Dahl-S rats. We measured systolic BP (by tail-cuff plethysmography), aortic PWV (by echocardiography) and CBF and N-acetyl aspartate (NAA) (by magnetic resonance imaging) in 6 month-old male Dahl-S rats (n = 12). RESULTS: Greater PWV was significantly associated with lower CBF and lower NAA concentration in the hippocampus, supporting a role of CAS in cerebrovascular dysfunction and decline in cognitive performance with aging. CONCLUSION: These findings implicate increased CAS in cerebral hypoperfusion and loss of neuronal density and function in the Dahl-S model of age-associated cardiovascular dysfunction.
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Ajamu et al. (2021) conducted a cross-sectional in Hypertension (n=12). Central arterial stiffness (aortic pulse wave velocity) was evaluated on Correlation between aortic pulse wave velocity and hippocampal cerebral blood flow (R2 0.79, p=<0.001). Greater central arterial stiffness, measured by aortic pulse wave velocity, was significantly associated with lower hippocampal cerebral blood flow (R2 0.79) and lower N-acetyl aspartate concentration.
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