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The SIBIS method for calculating the topographical steric map of biological receptor is described in detail. SIBIS is a self‐consistent type algorithm based upon a reference structure and which is well suited to delineate the main steric features of the receptor. Since the application of the method is not restricted to structurally congeneric molecules, the resultant steric map offers the linkage information to coanalyze structurally different compounds exhibiting common biological action. The molecular structure descriptor vector used in SIBIS permits the development of a simple method for quantitatively comparing the degree of relatedness of the shape of bio‐organic molecules exhibiting the same biological action but which may vary widely in their shape.
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Ioan Moţoc (1984) studied this question.
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