November 1, 1983Journal of Cardiovascular Pharmacology
Mediation of Subacute Anthracycline Cardiotoxicity in Rabbits by Cardiac Histamine Release
Why the study?
Does cromolyn sodium pretreatment prevent doxorubicin-induced cardiac histamine release and subacute cardiotoxicity in rabbits?
Population
New Zealand white rabbits and isolated rabbit heart preparations
Comparison
Doxorubicin 20 mg/kg i.v. over 30 min or 1, 5… vs No cromolyn sodium pretreatment (implied)
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Cromolyn sodium protects against doxorubicin cardiotoxicity in rabbits; leaves open clinical translation and human relevance.
Structured PICO
Does cromolyn sodium pretreatment prevent doxorubicin-induced cardiac histamine release and subacute cardiotoxicity in rabbits?
P
Population
New Zealand white rabbits and isolated rabbit heart preparations
I
Intervention
Doxorubicin (DXR) 20 mg/kg i.v. over 30 min (in vivo) or 1, 5, and 25 micrograms/ml (isolated hearts), with cromolyn sodium pretreatment (10 microM in isolated hearts, and in animals)
C
Comparator
No cromolyn sodium pretreatment (implied)
O
Outcome
Myocardial damage at 24 hours and cardiac histamine releasesurrogate
Cardiac histamine release may mediate subacute anthracycline cardiotoxicity, and cromolyn sodium offers significant protection in a rabbit model.
Cite This Study
Bristow et al. (1983) studied this question.