What question did this study set out to answer?

To evaluate whether functional polymorphisms in IL-1α, IL-1β, and TNFα, individually and in composite genotypes, associate with peri-implant disease susceptibility.

October 5, 2021PLoS ONEOpen Access

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

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Authors

QJQiuchen JinCentral Hospital of Wuhan FTFangjun TengCentral Hospital of Wuhan ZCZhigang ChengHuazhong University of Science and Technology

Discussion

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Implication

Meta-analysis reveals increased peri-implant disease risk linked to interleukin-1 variants in dental implant recipients, indicating potential utility as genetic predictive biomarkers.

Key Points

To evaluate whether functional polymorphisms in IL-1α, IL-1β, and TNFα, individually and in composite genotypes, associate with peri-implant disease susceptibility.
Searched literature databases prior to April 30, 2021, for studies on IL-1α C-889T, IL-1β C+3954T, IL-1β C-511T, TNFα G-308A, and an IL-1 composite genotype.
Included 27 studies comprising 1,324 cases with peri-implant disease (peri-implantitis, marginal bone loss, implant failure) and 1,808 controls with healthy implants.
Calculated odds ratios (ORs) and 95% confidence intervals (CIs) across genetic models and carrier status.
IL-1β C+3954T was associated with elevated peri-implant disease risk in allelic (OR = 1.66, 95% CI 1.17–2.35, p = 0.004) and dominant models (OR = 1.74, 95% CI 1.19–2.53, p = 0.004), while IL-1α C-889T correlated with disease across all genetic models.
The TT genotype of IL-1β C-511T increased overall peri-implant disease risk (OR = 1.68, 95% CI 1.15–2.43, p = 0.007) and marginal bone loss (OR = 4.33, 95% CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes.
Composite IL-1 genotype carriers had higher risks of peri-implant disease (OR = 1.95, 95% CI 1.35–2.80, p < 0.001) and implant failure (OR = 1.76, 95% CI 1.05–2.95, p = 0.032), whereas TNFα G-308A demonstrated no significant association.

Cite This Study

Jin et al. (2021) studied this question.

synapsesocial.com/papers/6a71e33ee5469ee92be22e00 https://doi.org/10.1371/journal.pone.0258138

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Implication

Meta-analysis reveals increased peri-implant disease risk linked to interleukin-1 variants in dental implant recipients, indicating potential utility as genetic predictive biomarkers.

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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