Population
Pentobarbital-anesthetized pigs, divided into four groups
Comparison
Clevidipine infused over 5 minutes through a… vs Nonischemic control pigs receiving the same…
Design
Preclinical, randomly divided into four groups
Follow-up
60 minutes of reperfusion
Authors
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Supports local intracoronary clevidipine cardioprotection in animals without systemic effects; leaves open human translation pending trials.
Local intracoronary administration of clevidipine provides cardioprotection without reaching systemic pharmacologically active levels due to its ultrashort half-life.
Wang et al. (2002) studied this question.
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