Key result
Artificially increasing fluid shear stress via an arteriovenous shunt restored maximal collateral conductance to 100% at day 7 and surpassed normal vasculature 2-fold after 4 weeks.
Population
Animal model with femoral artery occlusion
Comparison
Artificially increasing fluid shear stress via… vs Natural adaptation to femoral artery occlusion /…
Design
Preclinical
Follow-up
4 weeks
Authors
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May guide shear stress-based collateral therapies in ischemia; leaves open whether arteriovenous shunts translate to patients.
Absolute Event Rate: 100% vs 35%
Artificially increasing fluid shear stress can overcome anatomical restrictions and completely restore maximal collateral conductance via Ras-ERK, Rho, and NO pathways.
Eitenmüller et al. (2006) studied Femoral artery occlusion. Artificially increased fluid shear stress via arteriovenous shunt vs. Natural adaptation was evaluated on Adenosine-recruitable maximal conductance (C(max)). Artificially increasing fluid shear stress via an arteriovenous shunt restored maximal collateral conductance to 100% at day 7 and surpassed normal vasculature 2-fold after 4 weeks.
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