Key result
Selective MMP inhibition with SB-3CT and MMP-9 knockout significantly reduced flow-induced outward vascular remodeling in mice, whereas doxycycline and MMP-12 knockout did not.
Why the study?
Does MMP inhibition or genetic knockout reduce flow-induced outward vascular remodeling in mice?
Population
Mice subjected to a flow-augmented common carotid artery model (ligation of the left common carotid artery)
Comparison
MMP inhibition via pharmacological agents or… vs Control mice
Design
Preclinical
Authors
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MMP-9 inhibition attenuates remodeling in mice; leaves open translation to human vascular disease.
Does MMP inhibition or genetic knockout reduce flow-induced outward vascular remodeling in mice?
Matrix metalloproteinases, specifically MMP-9, play a critical role in mediating flow-induced outward vascular remodeling in a mouse model.
Ota et al. (2009) studied Flow-induced outward vascular remodeling. MMP inhibition (doxycycline, SB-3CT) or MMP knockout (MMP-9, MMP-12) vs. Control/wild-type was evaluated on Flow-induced outward vascular remodeling. Selective MMP inhibition with SB-3CT and MMP-9 knockout significantly reduced flow-induced outward vascular remodeling in mice, whereas doxycycline and MMP-12 knockout did not.
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