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March 21, 2006Human Molecular GeneticsOpen Access

Inhibition of Ca2+/calmodulin signaling reduced A-utrophin levels and exacerbated the dystrophic phenotype in mdx/CaMBP slow fibers.

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Population

mdx mice crossbred with transgenic mice expressing a small peptide inhibitor for calmodulin, driven by the…

Design

Preclinical

Authors

JCJoe V. ChakkalakalSMStephanie A. MichelECEva R. Chin

Discussion

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Overview

Ca2+/calmodulin inhibition worsens mdx dystrophy; hypothesis-generating for slow-fiber promotion in Duchenne muscular dystrophy.

Structured PICO

P
Population
mdx mice crossbred with transgenic mice expressing a small peptide inhibitor for calmodulin (CaMBP), driven by the slow fiber-specific troponin I slow promoter
I
Intervention
Targeted inhibition of Ca2+/calmodulin signaling via expression of CaMBP
O
Outcome
Dystrophic phenotype and A-utrophin expression in slow muscle fiberssurrogate

Targeted inhibition of Ca2+/calmodulin signaling exacerbates the dystrophic phenotype in mdx mice, highlighting the therapeutic potential of promoting the slow oxidative myofiber program for Duchenne muscular dystrophy.

Cite This Study

Chakkalakal et al. (2006) studied this question.

synapsesocial.com/papers/6a71e4ab5d37378ac1dee4b3https://doi.org/10.1093/hmg/ddl065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Membrane abnormalities and Ca homeostasis in muscles of the mdx mouse, an animal model of the Duchenne muscular dystrophy: a review1996 · 102 citations
  2. 2Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment2018 · 13 citations
  3. 3Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy2009 · 180 citations
  4. 4Effect of cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca‐ATPase, on skeletal muscles from normal and mdx mice2005 · 31 citations
  5. 5Transcriptomic profiling of skeletal muscle in the DMDmdx rat model of Duchenne muscular dystrophy2025 · 4 citations