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April 28, 2009Human Molecular GeneticsOpen Access

Deletion of the Mmp9 gene or pharmacological inhibition of MMP-9 improved skeletal muscle structure and functions, reduced muscle injury, inflammation, and fiber necrosis, and significantly augmented skeletal muscle regeneration in mdx mice.

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Why the study?

Does MMP-9 inhibition ameliorate pathogenesis and improve skeletal muscle regeneration in dystrophin-deficient mdx mice?

Population

Dystrophin-deficient mdx mice (animal model for Duchenne muscular dystrophy)

Comparison

Deletion of Mmp9 gene, pharmacological… vs Untreated mdx mice

Design

Preclinical

Authors

HLHong LiAMAshwani MittalDMDenys Y. Makonchuk

Discussion

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Overview

MMP-9 inhibition merits further preclinical testing in muscular dystrophy; leaves open translation to human efficacy and safety.

Structured PICO

Does MMP-9 inhibition ameliorate pathogenesis and improve skeletal muscle regeneration in dystrophin-deficient mdx mice?

P
Population
Dystrophin-deficient mdx mice (animal model for Duchenne muscular dystrophy)
I
Intervention
Deletion of Mmp9 gene, pharmacological inhibition of MMP-9 activity, and in vivo administration of nuclear factor-kappa B inhibitory peptide (NBD)
C
Comparator
Untreated mdx mice
O
Outcome
Skeletal muscle structure and function, muscle injury, inflammation, fiber necrosis, and skeletal muscle regenerationsurrogate

Inhibition of MMP-9 ameliorates skeletal muscle pathogenesis and enhances regeneration in a mouse model of Duchenne muscular dystrophy, identifying it as a promising therapeutic target.

Cite This Study

Li et al. (2009) studied this question.

synapsesocial.com/papers/6a716d6a75498292b70ae703https://doi.org/10.1093/hmg/ddp191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osteopontin-Stimulated Expression of Matrix Metalloproteinase-9 Causes Cardiomyopathy in the mdx Model of Duchenne Muscular Dystrophy2011 · 68 citations
  2. 2MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy2026
  3. 3Pattern of metalloprotease activity and myofiber regeneration in skeletal muscles of mdx mice2008 · 40 citations
  4. 4Transcriptomic profiling of skeletal muscle in the DMDmdx rat model of Duchenne muscular dystrophy2025 · 4 citations
  5. 5Characterisation of Progressive Skeletal Muscle Fibrosis in the Mdx Mouse Model of Duchenne Muscular Dystrophy: An In Vivo and In Vitro Study2022 · 33 citations