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The research investigates the role of MMP-10 in muscle regeneration after injury and in Duchenne muscular dystrophy.

February 13, 2026Open Access

MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy

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Demonstrates that MMP-10 supports muscle regeneration in injuries and muscular dystrophy, implying its potential as a therapeutic target.

The research investigates the role of MMP-10 in muscle regeneration after injury and in Duchenne muscular dystrophy.
Assessment of MMP-10 expression in mouse models following injury and in dystrophic models.
Comparison of muscle regeneration in wild-type and MMP-10 deficient mice.
Local delivery of recombinant MMP-10 to evaluate effects on muscle repair.
Analysis of endothelial cell recruitment and myofiber formation post-injury.
MMP-10 deficiency leads to impaired muscle regeneration, with smaller regenerating fibers and delayed myofiber formation.
Increased muscle degeneration in mdx mice lacking MMP-10, worsening the dystrophic phenotype.
Local delivery of MMP-10 accelerates muscle repair and regeneration.
MMP-10 promotes myoblast fusion and activates VEGF/Akt signaling pathway.

Bobadilla et al. (2026) studied this question.

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February 13, 2026Open Access

View Full Paper

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Authors

Demonstrates that MMP-10 supports muscle regeneration in injuries and muscular dystrophy, implying its potential as a therapeutic target.

The research investigates the role of MMP-10 in muscle regeneration after injury and in Duchenne muscular dystrophy.
Assessment of MMP-10 expression in mouse models following injury and in dystrophic models.
Comparison of muscle regeneration in wild-type and MMP-10 deficient mice.
Local delivery of recombinant MMP-10 to evaluate effects on muscle repair.
Analysis of endothelial cell recruitment and myofiber formation post-injury.
MMP-10 deficiency leads to impaired muscle regeneration, with smaller regenerating fibers and delayed myofiber formation.
Increased muscle degeneration in mdx mice lacking MMP-10, worsening the dystrophic phenotype.
Local delivery of MMP-10 accelerates muscle repair and regeneration.
MMP-10 promotes myoblast fusion and activates VEGF/Akt signaling pathway.

Bobadilla et al. (2026) studied this question.

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