Key result
Genetic ablation of MMP-9 attenuated cardiac injury, left ventricle dilation, and fibrosis, and improved heart function in 1-year-old mdx mice.
Why the study?
Does genetic ablation of MMP-9 prevent cardiomyopathy in the mdx mouse model of Duchenne muscular dystrophy?
Population
1-year-old mdx mice (model of Duchenne muscular dystrophy)
Comparison
Genetic ablation of MMP-9 vs mdx mice with intact MMP-9
Design
Preclinical
Follow-up
1 year
Authors
Loading...
Hypothesis-generating for MMP-9 inhibition in DMD cardiomyopathy; leaves open translation to patients.
Does genetic ablation of MMP-9 prevent cardiomyopathy in the mdx mouse model of Duchenne muscular dystrophy?
Genetic ablation of MMP-9 attenuates cardiac injury and improves heart function in a mouse model of Duchenne muscular dystrophy, suggesting MMP-9 and osteopontin as potential therapeutic targets.
Dahiya et al. (2011) studied Duchenne muscular dystrophy cardiomyopathy. Genetic ablation of MMP-9 vs. MMP-9 wildtype mdx mice was evaluated on Cardiac injury, left ventricle dilation, fibrosis, and heart function. Genetic ablation of MMP-9 attenuated cardiac injury, left ventricle dilation, and fibrosis, and improved heart function in 1-year-old mdx mice.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: