Key result
Intracoronary administration of the MMP inhibitor GM-2487 did not prevent or attenuate myocardial expansion or contractile dysfunction after moderate ischemia and reperfusion in pigs.
Why the study?
Does intracoronary administration of the MMP inhibitor GM-2487 prevent myocardial expansion or contractile dysfunction in a pig model of moderate ischemia and reperfusion?
Population
Open-chest anesthetized pigs undergoing 90 min of regional ischemia (subendocardial blood flow 0.4 +/- 0.1…
Design
Preclinical
Follow-up
90 minutes of reperfusion
Authors
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MMP inhibition may reduce stunning-related dysfunction; extends matrix remodeling role to reversible ischemia without infarction.
Does intracoronary administration of the MMP inhibitor GM-2487 prevent myocardial expansion or contractile dysfunction in a pig model of moderate ischemia and reperfusion?
Moderate ischemia and reperfusion increase myocardial MMP content and activity, but this does not damage interstitial collagen or contribute to myocardial expansion or contractile dysfunction.
Li et al. (2000) studied Moderate myocardial ischemia and reperfusion. MMP inhibitor GM-2487 was evaluated on Myocardial expansion or contractile dysfunction. Intracoronary administration of the MMP inhibitor GM-2487 did not prevent or attenuate myocardial expansion or contractile dysfunction after moderate ischemia and reperfusion in pigs.
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