Key result
Ischemia and reperfusion increased MT1-MMP activity by >40% and abundance by >50% in the ischemic myocardium of pigs (P<0.05), likely due to changes in intracellular trafficking.
Population
Pigs (30 kg, n=8) and an isolated left ventricular myocyte model
Comparison
Ischemia followed by reperfusion in vivo, and… vs Nonischemic myocardium and baseline states
Design
Preclinical
Follow-up
90 minutes ischemia, 120 minutes reperfusion
Authors
Loading...
May implicate MT1-MMP in I/R injury; hypothesis-generating for targeted therapies pending human validation.
p-value: p=<0.05
MT1-MMP abundance and activity increase during myocardial ischemia and reperfusion, likely driven by changes in intracellular trafficking.
Deschamps et al. (2005) studied Ischemia and reperfusion (n=8). Ischemia and reperfusion vs. Nonischemic (remote) myocardium was evaluated on MT1-MMP activity and abundance (p=<0.05). Ischemia and reperfusion increased MT1-MMP activity by >40% and abundance by >50% in the ischemic myocardium of pigs (P<0.05), likely due to changes in intracellular trafficking.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: