Key result
Myocardial reperfusion during cardiopulmonary bypass is linked to a ~30% increase in interstitial MMP activity.
Why the study?
Does myocardial arrest and reperfusion alter interstitial MMP activity in patients undergoing elective cardiac surgery?
Observational (n=14)
Does myocardial arrest and reperfusion alter interstitial MMP activity in patients undergoing elective cardiac surgery?
p-value: p=<0.05
This study provides direct in vivo evidence that interstitial MMP proteolytic activity in the human myocardium is dynamic and increases significantly during ischemia and reperfusion.
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First direct human myocardial interstitial MMP activity measurements during ischemia/reperfusion now feasible; extends mechanistic understanding but leaves open therapeutic implications.
Spinale et al. (2008) conducted an observational in Patients undergoing elective cardiac surgery (n=14). Myocardial arrest and reperfusion during cardiopulmonary bypass vs. Baseline (steady-state conditions) was evaluated on Interstitial MMP activity (p=<0.05). Myocardial arrest and reperfusion during cardiopulmonary bypass dynamically altered interstitial MMP activity, which increased by over 30% from baseline upon restoration of blood flow (P<0.05).
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