Key result
Novel Zn-Ni MOF sensor enables ultratrace doxorubicin detection down to ~0.001 μM.
Why the study?
Does the Zn-Ni MOF NSs@GO/SPCE sensor improve the sensitive determination of doxorubicin compared to a bare electrode?
Does the Zn-Ni MOF NSs@GO/SPCE sensor improve the sensitive determination of doxorubicin compared to a bare electrode?
The developed Zn-Ni MOF NSs@GO/SPCE sensor provides a highly sensitive and cost-effective platform for doxorubicin detection, which may facilitate therapeutic drug monitoring to prevent cardiotoxicity.
Provides sensitive doxorubicin detection for research samples; leaves open clinical validation for therapeutic monitoring to mitigate cardiotoxicity.
Background and purpose: Doxorubicin (DOX) serves as an anthracycline-based chemotherapy drug to treat multiple types of cancers and sarcomas, which include lung, breast, bladder, leukaemia, liver, head and neck cancers. Experimental approach: The electroanalysis of the trace level of DOX in this study was conducted using a Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite (Zn-Ni MOF NSs@GO) after the modification of a screen-printed carbon electrode (Zn-Ni MOF NSs@GO/SPCE). Using chronoamperometry, cyclic voltammetry and differential pulse voltammetry, the electrochemical characteristics of the sensor as constructed for DOX measurement were examined. Key results: Consequently, the composite sensor demonstrated exceptional electrocatalytic performance in oxidizing DOX within a concentration range of 0.004 to 190.0 μM, with a detection limit of 0.001 μM. It was found that the Zn-Ni MOF NSs@GO/SPCE was effective at determining DOX in real samples, with good recovery values in the 97.1 to 102.0 % range. Conclusion: The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.
No takes yet. Share an insight, caveat, or question.
Kondori et al. (2026) studied this question. Zn-Ni MOF NSs@GO/SPCE sensor vs. Bare SPCE was evaluated on Doxorubicin detection limit and linear range. The Zn-Ni MOF NSs@GO/SPCE sensor demonstrated exceptional electrocatalytic performance for doxorubicin detection with a linear range of 0.004 to 190.0 μM and a detection limit of 0.001 μM.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: