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Preclinical study demonstrates tumor growth changes under endocrine therapy reflect hormone dependency in xenografted mice, highlighting links to steroid receptor levels.
Since human mammary cancer can be transplanted into nude mice, this makes possible the in vivo study of relations between hormone dependency and the steroid hormone receptor content of the tumors. The macroscopic growth curve of the transplanted tumors during endocrine therapy will reflect the hormone dependency. The results can be compared with successive steroid hormone receptor determinations in the tumor tissue.
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Brünner et al. (1981) studied this question.
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