Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1998The Journal of PhysiologyOpen Access

Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells

View Full Paper
Ask AI
Bookmark
Share

Population

Adult rat single ventricular myocytes

Design

Preclinical

Authors

YXYong‐Fu XiaoNewark AcademyLHLin HuangZhejiang Chinese Medical UniversityJMJames P. MorganGeneral Cardiology

Discussion

Loading...

Member takes

Implication

Animal data on P450 metabolites in cardiac contraction are hypothesis-generating; leaves open translation to human disease or therapy.

Structured PICO

P
Population
Adult rat single ventricular myocytes
I
Intervention
P450 inhibitors (clotrimazole, econazole, miconazole), P450 antibody anti-rat CYP1A2, and 11,12-epoxyeicosatrienoic acid
O
Outcome
L-type Ca2+ current (ICa), intracellular free Ca2+ signals, and cell shorteningsurrogate

Cytochrome P450 modulates cardiac L-type calcium currents and cell contraction, likely through changes in intracellular cAMP mediated by arachidonic acid metabolites.

Cite This Study

Xiao et al. (1998) studied this question.

synapsesocial.com/papers/6a71e77935aa2c282ce2fe0fhttps://doi.org/10.1111/j.1469-7793.1998.777bp.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of the frequency‐dependent facilitation of L‐type Ca2+ currents in rat ventricular myocytes.1994 · 60 citations
  2. 2Elevated density and altered pharmacologic properties of myocardial calcium current of the spontaneously hypertensive rat1994 · 36 citations
  3. 3A G Protein Directly Regulates Mammalian Cardiac Calcium Channels1987 · 549 citations
  4. 4Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's1993 · 881 citations