April 1, 1999Journal of Biological ChemistryOpen Access

Ile-177 and Ser-180 in the S1 Segment Are Critically Important in Kv1.1 Channel Function

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Population

Xenopus oocytes, COS-7 cells, and Sol8 cells

Comparison

Mutation of Ile-177 and Ser-180 in Kv1.1 to… vs Wild-type Kv1.1

Design

Preclinical

Authors

RMRajesh S. MathurUniversity of Freiburg JZJun ZhouUniversity of Michigan TBTamar BabilaBrigham and Women's Hospital

Discussion

Member takes

Implication

May inform Kv1.1 channelopathy models; leaves open cardiac translation pending human validation.

Structured PICO

Population

Xenopus oocytes, COS-7 cells, and Sol8 cells

Intervention

Mutation of Ile-177 and Ser-180 in Kv1.1 to leucine, proline, or arginine

Comparator

Wild-type Kv1.1

Outcome

Expression of outward potassium currents, channel assembly, and membrane targetingsurrogate

Ile-177 and Ser-180 in the S1 segment are essential for Kv1.1 channel function, likely mediating critical helix-helix interactions rather than affecting assembly or trafficking.

Cite This Study

Mathur et al. (1999) studied this question.

synapsesocial.com/papers/6a71e8a5af0c21e9392938aa https://doi.org/10.1074/jbc.274.17.11487

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Ile-177 and Ser-180 in the S1 Segment Are Critically Important in Kv1.1 Channel Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ile-177 and Ser-180 in the S1 Segment Are Critically Important in Kv1.1 Channel Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider