What question did this study set out to answer?

To establish a computational framework for detecting alpha-helix-forming molecular recognition elements that undergo coupled folding and binding within intrinsically disordered protein regions.

August 24, 2005Biochemistry

Coupled Folding and Binding with α-Helix-Forming Molecular Recognition Elements

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To establish a computational framework for detecting alpha-helix-forming molecular recognition elements that undergo coupled folding and binding within intrinsically disordered protein regions.
Engineered a discriminant function designed to detect short alpha-helix-forming regions embedded within disordered sequences while minimizing false-positive errors on structured protein sets.
Screened genomic sequences and functionally annotated protein databases to evaluate the prevalence and functional contexts of these recognition elements.
Demonstrated accurate detection of alpha-helical molecular recognition elements with low false-positive error rates when evaluated on extensive collections of structured proteins.
Revealed that identified recognition elements are enriched across functionally annotated proteins, pointing to essential roles in mediating protein-protein interactions during cell signaling.

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Implication

Computational analysis reveals short disordered segments that fold into alpha-helices upon binding across genomic databases, highlighting their widespread regulatory roles in cellular signaling.

Cite This Study

Oldfield et al. (2005) studied this question.

synapsesocial.com/papers/6a71e96f2163a0a01bc5d7f6 https://doi.org/10.1021/bi050736e

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Implication

Computational analysis reveals short disordered segments that fold into alpha-helices upon binding across genomic databases, highlighting their widespread regulatory roles in cellular signaling.

Coupled Folding and Binding with α-Helix-Forming Molecular Recognition Elements

Key Points

Discussion

Implication

Cite This Study

Coupled Folding and Binding with α-Helix-Forming Molecular Recognition Elements

Key Points

Discussion

Implication

Cite This Study

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