What question did this study set out to answer?

To determine whether antibody responses to HERV-K envelope proteins are antigen-driven and assess their prevalence across healthy individuals and patients with autoimmune rheumatic diseases.

April 1, 2002Clinical & Experimental ImmunologyOpen Access

Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes

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Authors

CHChristine HervéElectrical Geodesics (United States)ELElena B. LugliNatural History Museum ABAlexander BrandUniversity Hospital Leipzig

Discussion

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Implication

Cross-sectional study reveals multi-epitope HERV-K autoantibodies across healthy and autoimmune cohorts, suggesting an antigen-driven trigger for tolerance breakdown.

Key Points

To determine whether antibody responses to HERV-K envelope proteins are antigen-driven and assess their prevalence across healthy individuals and patients with autoimmune rheumatic diseases.
Evaluated antibody reactivity against recombinant HERV-K10 and IDDMK1,222 Env proteins using immunoblotting in sera from patients with autoimmune rheumatic disease (N=84) and normal controls (N=35).
Performed epitope mapping with overlapping 15-mer peptides and quantified antibody titers against an identified immunodominant peptide using ELISA in patients with SLE (N=39), healthy controls (N=39), and other rheumatic diseases (N=86).
Immunoblotting identified anti-Env antibodies in 32% to 47% of sera from patients with autoimmune rheumatic disease (N=84) and in 29% of healthy controls (N=35).
Epitope mapping revealed multiple reactive sites, with one immunodominant peptide (GKTCPKEIPKGSKNT) showing significantly elevated median antibody titers in SLE compared to healthy controls and other rheumatic diseases (P < 0.003).

Cite This Study

Hervé et al. (2002) studied this question.

synapsesocial.com/papers/6a71e9e6b27f15817827e1cb https://doi.org/10.1046/j.1365-2249.2002.01735.x

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Implication

Cross-sectional study reveals multi-epitope HERV-K autoantibodies across healthy and autoimmune cohorts, suggesting an antigen-driven trigger for tolerance breakdown.

Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes

Discussion

Member takes

Implication

Key Points

Cite This Study

Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes

Discussion

Member takes

Implication

Key Points

Cite This Study

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