January 1, 2021Chemical ScienceOpen Access

Thermodynamics of ion binding and occupancy in potassium channels

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Population

Potassium channels

Design

Computational simulation study

Authors

ZJZhifeng JingCubist Pharmaceuticals (United States)JRJoshua A. RackersSandia National Laboratories California LPLawrence R. PrattTulane University

Discussion

Member takes

Implication

Challenges prior ion conduction models; leaves open physiological relevance pending experimental validation.

Structured PICO

Population

Potassium channels (computational model)

Intervention

Computational simulations incorporating complex electrostatic interactions, dielectric screening, and polarization

Outcome

Thermodynamic stability of ion binding configurations and ion conduction mechanism

Accounting for polarization in simulations reveals that the four-ion configuration in potassium channels is thermodynamically stable, supporting a water-free conduction mechanism.

Cite This Study

Jing et al. (2021) studied this question.

synapsesocial.com/papers/6a71e9fda528af2d65c43f1b https://doi.org/10.1039/d1sc01887f

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Thermodynamics of ion binding and occupancy in potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thermodynamics of ion binding and occupancy in potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider