What question did this study set out to answer?

To determine whether dextran sulphate sodium (DSS)-induced experimental intestinal inflammation responds to established human inflammatory bowel disease therapies.

September 1, 1998Alimentary Pharmacology & Therapeutics

Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine

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Authors

LAL.‐G. AxelssonKarolinska University Hospital ELE. LandströmUppsala University ABAnn‐Christin Bylund‐FelleniusSahlgrenska University Hospital

Discussion

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Implication

Animal study demonstrates that sulphasalazine and olsalazine ameliorate dextran sulphate sodium-induced colitis in mice, indicating the therapeutic efficacy of liberated 5-aminosalicylic acid.

Key Points

To determine whether dextran sulphate sodium (DSS)-induced experimental intestinal inflammation responds to established human inflammatory bowel disease therapies.
DSS was administered to conventional Balb/c mice and athymic nu/nu CD-1(BR) mice to induce experimental colitis.
Mice were treated with sulphasalazine (SASP) or olsalazine (OLZ) across a dose-dependent range of 10 to 100 mg/kg/day.
Assessed disease activity markers (body weight, colon length, spleen weight, diarrhoea, and rectal bleeding) in Balb/c mice and recorded survival in nu/nu CD-1 mice.
SASP and OLZ treatments significantly ameliorated weight loss, colon shortening, spleen enlargement, diarrhoea, and rectal bleeding in Balb/c mice.
In nu/nu CD-1 mice with a 50% mortality rate at day 16, SASP (100 mg/kg/day) and OLZ (50 mg/kg/day) significantly prolonged survival to 29 and 38 days, respectively.
Both agents exhibited dose-dependent efficacy between 10 and 100 mg/kg/day, indicating that liberated 5-aminosalicylic acid represents the primary active therapeutic moiety.

Cite This Study

Axelsson et al. (1998) studied this question.

synapsesocial.com/papers/6a71ea362163a0a01bc5d858 https://doi.org/10.1046/j.1365-2036.1998.00357.x

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Implication

Animal study demonstrates that sulphasalazine and olsalazine ameliorate dextran sulphate sodium-induced colitis in mice, indicating the therapeutic efficacy of liberated 5-aminosalicylic acid.

Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine

Discussion

Member takes

Implication

Key Points

Cite This Study

Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine

Discussion

Member takes

Implication

Key Points

Cite This Study

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