Why the study?
Does genetic deletion of the angiotensin-(1-7) receptor Mas impair heart function in mice?
Population
Angiotensin-(1-7) receptor Mas knockout mice (Mas-/-) and wild-type mice (Mas+/+)
Comparison
Genetic deletion of the angiotensin- receptor Mas vs Wild-type mice (Mas+/+)
Design
Preclinical
Authors
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Mas deletion impairs murine cardiac function; hypothesis-generating for Ang-(1-7)-Mas axis targeting in human cardiovascular disease.
Does genetic deletion of the angiotensin-(1-7) receptor Mas impair heart function in mice?
The Ang-(1-7)-Mas axis plays a key role in maintaining cardiac structure and function, as its deletion leads to impaired heart function and a profibrotic profile in mice.
Santos et al. (2006) studied this question.
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