November 1, 1991BloodOpen Access

Alpha-2-macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children

View Full Paper

Ask AI

Bookmark

Population

52 individuals including 14 ATIII-deficient adults, 13 ATIII-deficient children, 9 normal children, and 16…

Design

Cross-sectional

Authors

LMLesley MitchellSemmelweis University FPFranco PiovellaVascular / Pulmonary Vascular FOFrederick A. OfosuGhana Health Service

Discussion

Member takes

Implication

May explain lower thrombosis risk in ATIII-deficient children; hypothesis-generating for alpha-2-macroglobulin modulation in adults.

Structured PICO

Population

52 individuals including 14 ATIII-deficient adults (ages 25 to 46 years), 13 ATIII-deficient children (ages 2 to 13 years), 9 normal children (ages 3 to 15 years), and 16 normal adults.

Outcome

Thrombin inhibition in plasmasurrogate

Elevated alpha-2-macroglobulin levels in childhood may protect ATIII-deficient children from thromboembolic complications by maintaining normal thrombin inhibition capacity.

Cite This Study

Mitchell et al. (1991) studied this question.

synapsesocial.com/papers/6a71eba1ac440176ef2a6b56 https://doi.org/10.1182/blood.v78.9.2299.2299

View Full Paper

Ask AI

Bookmark

Alpha-2-macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alpha-2-macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider