Undiagnosed protein C deficiency is a rare but potentially fatal cause of perioperative pulmonary embolism in pediatric patients.
Case of fatal perioperative PE from undiagnosed protein C deficiency; hypothesis-generating for targeted preoperative screening in pediatrics.
Pulmonary embolism in the perioperative period is associated with significant morbidity and mortality. Deficiency of protein C, a vitamin K-dependent anticoagulant that inhibits activated factors V and VIII, is a rare cause of thromboembolic phenomena. We report a case of perioperative pulmonary embolism secondary to undiagnosed protein C deficiency and resulting in nonresuscitable cardiac arrest in a pediatric patient
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Sternberg et al. (1991) studied this question.
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