What question did this study set out to answer?

Investigate whether local renin expression in the coagulating glands of developing and adult mice depends on sexual maturation and testosterone regulation.

April 1, 1995The Anatomical Record

Expression of renin in coagulating glands is regulated by testosterone

View Full Paper

Ask AI

Bookmark

Population

44 male C57BL/6 mice, aged 3 wk to 6 mo

Comparison

Castration followed by testosterone injection vs Pre-castration baseline and developmental stages

Design

Preclinical

Follow-up

Up to 4 weeks post-castration and 3 weeks…

Authors

YKYasuhiro KonHokkaido University DEDaiji EndohTokyo University of Agriculture KMKazuo MurakamiMeijo University

Discussion

Member takes

Implication

Mouse data on testosterone-renin regulation warrant no clinical change; leaves open relevance to human prostate or cardiovascular tissues.

Key Points

Investigate whether local renin expression in the coagulating glands of developing and adult mice depends on sexual maturation and testosterone regulation.
Examined 44 male C57BL/6 mice aged 3 weeks to 6 months to evaluate coagulating gland renin ontogeny.
Performed surgical castration and subsequent testosterone replacement therapy in adult mice.
Quantified renin-containing epithelial cells in coagulating gland terminal ducts using antirenin immunohistochemistry on Bouin-fixed paraffin sections.
Renin immunoreactivity appeared at 6 weeks of age and progressively increased into adulthood, exhibiting basolateral, cytoplasmic, and nuclear localization in epithelial cells.
Castration induced a persistent reduction in renin-positive terminal duct cells from day 10 through week 4.
Testosterone replacement restored elevated levels of renin-containing cells by week 1, followed by a decline at weeks 2 to 3.

Structured PICO

Population

44 male C57BL/6 mice, aged 3 wk to 6 mo

Intervention

Castration followed by testosterone injection

Comparator

Pre-castration baseline and developmental stages

Outcome

Relative number of renin-containing cells in terminal portions of the coagulating glandsurrogate

In a mouse model, renin expression in the coagulating gland is dependent on sexual maturation and regulated by testosterone.

Cite This Study

Kon et al. (1995) studied this question.

synapsesocial.com/papers/6a71ee1f31a3df824329e018 https://doi.org/10.1002/ar.1092410403

View Full Paper

Ask AI

Bookmark

Implication

Mouse data on testosterone-renin regulation warrant no clinical change; leaves open relevance to human prostate or cardiovascular tissues.

Expression of renin in coagulating glands is regulated by testosterone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Expression of renin in coagulating glands is regulated by testosterone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider