Angiotensin-like immunoreactivity is localized specifically to gonadotrops and lactotrops in the rat anterior pituitary gland.
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Suggests possible local angiotensin regulation of gonadotropins and prolactin in rodents; leaves open any human pituitary relevance.
Utilizing an immunocytochemical technique wherein two different antigens can be visualized on the same tissue section, angiotensin-like immunoreactivity was found in rat adenohypophyseal cells that showed staining with antisera to hLH, hFSH or human prolactin. Angiotensin-like immunoreactivity was not found in cells that showed staining with antisera to hTSH, C-terminal ACTH or hGH. The nature and possible physiologic significance of the angiotensin-like immunoreactivity is discussed.
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Steele et al. (2008) studied this question.
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