Key result
Angiotensin II localizes to corpora lutea and thecal cells, confirming a functional ovarian renin-angiotensin system.
Why the study?
The functional role and localization of angiotensin II and its binding in the rat ovary were not fully characterized.
Population
Rat ovaries from gonadotropin-stimulated immature rats, pseudopregnant adult rats, normal cycling rats, and unstimulated immature rats
Comparison
Angiotensin II immunoreactivity and binding across different ovarian states and cell types
Design
Preclinical immunocytochemical and in vitro autoradiography study
Authors
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Hypothesis-generating for ovarian RAS in reproduction; leaves open clinical relevance in human fertility.
The localization of angiotensin II immunoreactivity and cycle-related binding in rat ovaries supports a functional role for the ovarian renin-angiotensin system.
Lightman et al. (1988) studied this question. Angiotensin II immunoreactivity and binding was evaluated on Cellular localization of angiotensin II immunoreactivity and binding. Angiotensin II immunoreactivity was localized in corpora lutea and some stromal/thecal cells, with specific binding varying by estrous cycle, supporting a functional ovarian renin-angiotensin system.
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