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October 1, 1982Clinical Science

Regional Distribution of Angiotensinogen in the Central Nervous System of the Rat: Effect of DOC-Salt Treatment

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Population

Normal and DOC-salt-treated hypertensive rats

Comparison

DOC-salt treatment vs Normal (control) rats

Design

Preclinical

Follow-up

30 days

Authors

NBNidia BassoDGDiana GrisponPRPatricia Ruíz

Discussion

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Overview

Supports central angiotensin role in DOC-salt hypertension model; hypothesis-generating and should not yet change clinical practice.

Structured PICO

P
Population
Normal and DOC-salt-treated hypertensive rats
I
Intervention
DOC-salt treatment
C
Comparator
Normal (control) rats
O
Outcome
Distribution and concentration of angiotensinogen and endogenous renin-like activity in different areas of the central nervous systemsurrogate

Increased central nervous system angiotensinogen and renin-like activity in DOC-salt-treated rats suggests a role for central angiotensin formation in the development of DOC-salt hypertension.

Cite This Study

Basso et al. (1982) studied this question.

synapsesocial.com/papers/6a71ee2131a3df824329e026https://doi.org/10.1042/cs063149s
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin-like activity in the rat brain during the development of DOC-salt hypertension.1981 · 45 citations
  2. 2Adrenal Regulation of Regional Brain Angiotensinogen Content*1980 · 47 citations
  3. 3A “Renin-Like” Enzymatic Action of Cathepsin D and the Similarity in Subcellular Distributions of “Renin-Like” Activity and Cathepsin D in the Midbrain of Dogs*1978 · 35 citations
  4. 4Definitive Evidence for Renin in Rat Brain by Affinity Chromatographic Separation from Protease1978 · 29 citations
  5. 5Separation of dog brain renin-like activity from acid protease activity.1979 · 50 citations