Why the study?
Does a calcium antagonist and nitrate improve chest pain in patients with concurrent familial hypertrophic cardiomyopathy and vasospastic angina pectoris?
Does a calcium antagonist and nitrate improve chest pain in patients with concurrent familial hypertrophic cardiomyopathy and vasospastic angina pectoris?
The concurrent occurrence of familial hypertrophic cardiomyopathy and vasospastic angina pectoris can be effectively managed with calcium antagonists and nitrates to ameliorate chest pain.
May relieve chest pain in this rare overlap; hypothesis-generating and requires prospective confirmation before practice change.
Two brothers had familial hypertrophic cardiomyopathy and vasospastic angina pectoris concurrently. Their family history showed that one of their sisters had hypertrophic cardiomyopathy and another brother died suddenly at age 52. The clinical diagnosis of hypertrophic cardiomyopathy was confirmed by an echocardiogram and left ventriculography. They had typical chest pain at rest, and a significant vasospasm of coronary arteries with chest pain and obvious ST-T changes in the electrocardiograms was provoked by intracoronary injection of acetylcholine in both patients. The administration of a calcium antagonist and nitrate was effective for ameliorating chest pain with no cardiovascular events during the follow up period of more than 3 years. Although underlying pathophysiologic abnormalities of familial hypertrophic cardiomyopathy and vasospastic angina pectoris are considered to be transmitted genetically, the genetic backgrounds of these cases remain to be clarified.
No takes yet. Share an insight, caveat, or question.
Suzuki et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: