Why the study?
Do elevated C-reactive protein levels predict the progression of subclinical atherosclerosis in older adults?
Population
773 subjects ≥55 years of age participating in the Rotterdam Study
Comparison
Highest quartile of C-reactive protein levels vs Lowest quartile of C-reactive protein (CRP) levels
Design
Cohort
Follow-up
mean 6.5 years
Authors
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Elevated CRP may flag atherosclerosis progression risk in older adults; hypothesis-generating without randomized evidence to guide interventions.
Do elevated C-reactive protein levels predict the progression of subclinical atherosclerosis in older adults?
Elevated CRP levels independently predict the progression of subclinical atherosclerosis across multiple arterial beds over a 6.5-year period.
Meer et al. (2002) studied this question.
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