December 1, 2017APL BioengineeringOpen Access

Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension

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Population

Murine model of pulmonary arterial hypertension (PAH) and normal controls

Comparison

Pulmonary arterial hypertension vs Normal (non-hypertensive) myocardium

Design

Preclinical

Authors

RAReza AvazmohammadiCardiac Imaging MHMichael R. HillUniversity of California, Davis MSMarc A. SimonHeart Failure & Transplant

Discussion

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Implication

Hypothesis-generating for RVFW remodeling in PAH; leaves open experimental validation before clinical translation.

Structured PICO

Population

Murine model of pulmonary arterial hypertension (PAH) and normal controls

Intervention

Pulmonary arterial hypertension (pressure overload)

Comparator

Normal (non-hypertensive) myocardium

Outcome

Transmural mechanical and structural remodeling of the right ventricular free wall (RVFW)surrogate

In a murine model of PAH, right ventricular remodeling is dominated by midwall longitudinal reorientation of collagen and myofibers, resulting in increased longitudinal stiffness and stress.

Cite This Study

Avazmohammadi et al. (2017) studied this question.

synapsesocial.com/papers/6a71eef7a7fbea1e44088af1 https://doi.org/10.1063/1.5011639

View Full Paper

Ask AI

Bookmark

Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider