Why the study?
Detecting concomitant wild-type transthyretin cardiac amyloidosis in patients with aortic stenosis is challenging due to shared morphological left ventricular changes.
Answers are grounded in this paper and cite their sources.
A multimodality imaging approach is essential for the early detection of concomitant wild-type transthyretin cardiac amyloidosis in patients with severe aortic stenosis, which is critical for guiding appropriate therapeutic management.
Severe aortic stenosis (AS) is the most common valvular heart disease with a prevalence rate of more than 4% in 75-year-old people or older. Similarly, cardiac amyloidosis (CA), especially "wild-type transthyretin" (wTTR), has shown a prevalence rate ranging from 22% to 25% in people older than 80 years. The detection of the concomitant presence of CA and AS is challenging primarily because of the similar type of changes in the left ventricle caused by AS and CA, which share some morphological characteristics. The aim of this review is to identify the imaging triggers in order to recognize occult wtATTR-CA in patients with AS, clarifying the crucial step of the diagnostic process. Multimodality imaging methods such as echocardiography, cardiac magnetic resonance, cardiac computed tomography, and DPD scintigraphy will be analyzed as part of the available diagnostic workup to identify wtATTR-CA early in patients with AS.
No takes yet. Share an insight, caveat, or question.
Cersosimo et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: